Client Letters

Below are examples of the many letters Olis receives from users of our instruments.
Click on more to read the full text of each.

“In my opinion, the technological support that OLIS provides is without question way beyond what would be expected by any company! ... OLIS is truly a leader in instrumentation for people who are interested in a variety of problems in kinetic and mechanistic work.” ... more

—Michael D. Johnson, Ph.D.,
Associate Professor,
Department of Chemistry
New Mexico State University

“I have dealt with a lot of instrument vendors in my 15 years as an analytical chemistry professor, but I have never found a vendor as responsive and helpful after the sale as OLIS.” ... more

—Lawrence E. Welch,
Associate Professor and Chair, Chemistry
Knox College

“There is no other commercial instrument that comes close to this combination of capabilities.”... more

—Christopher Moser, Ph.D.,
Associate Director, Johnson Research Foundation

“Overall, I have been pleased in all my interactions with Olis. Their instruments, workmanship, technical expertise and assistance are all world class.” ... more

—Sriram Krishnaswamy,
University of Pennsylvania

“With signal averaging, we were able to obtain what I think are data that no one has previously reported—direct evidence of transition from random coil to alpha helix in the presence of increasing dioleoyl phosphotidylserine concentration
in vesicles. The data are spectacular.” ... more

—Thomas P. Sakmar, M.D.,
Rockefeller University

“To anyone looking at low light level chemiluminescent or bioluminescent reactions, or wishing to obtain spectral and kinetic data on transient or precious biological samples the rapid scanner is a must. A wonderful instrument!!” ... more

—Dr. Russell Hart,
SeaLite Sciences, Inc.

“I am continually amazed at the capabilities of the instrument...It is very exciting to gain new insight so quickly.” ... more

—Dr. Charles B. Grissom
The University of Utah

“...even the brief training my postdocs received on the Olis has allowed us to become quite comfortable in its operation. We have been using it as though it has always been in the lab.” ... more

—Dr. Paul F. Cook,
The University of Oklahoma

“I am more than satisfied with the performance of the machine and its versatility.” ... more

—Dr. Denise A. Mills,
Michigan State University

Letter from Russell Hart

SeaLite Sciences, Inc.

March 31, 1993

Dear Dick:

I am writing to express my thanks for the skill and help you and everyone at OLIS shows me. As you know I work with the bioluminescent photoprotein, Aequorin, which upon the addition of excess calcium produces a rapid flash of visible light. At SeaLite, we use this protein as a detection device for immunoassays. In my attempts to understand the conjugation chemistry we use, I had fluorescein labeled aequorin. This fluorescein labeled material now produced a different colored emission from the non-labeled protein.

Your instrument, although designed for absorption spectra, was quickly modified to measure the rapid flash produced. In our first experiments we took a few micrograms of the modified aequorin and triggered it. The individual 1 msec spectra looked awful, but the cumulative data showed the two emission peaks very clearly, with the correct positions for both aequorin and fluorescein emission. Our subsequent rapid scanned stopped flow emission spectra of this transient signal showed how good the detection capabilities of the instrument are. We were looking at very small amounts of the protein and obtained individual 1 msec emission spectra with excellent S/N. In a few hours we obtained quality data and spectra that are publication quality.

To anyone looking at low light level chemiluminescent or bioluminescent reactions, or wishing to obtain spectral and kinetic data on transient or precious biological samples the rapid scanner is a must. A wonderful instrument!!

Yours sincerely,

Russell Hart, D. Phil.
Director of Clinical Assays