DNA Structure/Conformation
The structure and conformation of DNA are important considerations in studying the interactions of DNA with proteins and other DNA ligands.  Techniques for determining DNA structure and conformation include X-ray crystallography, circular dichroism (CD), fluorescence, and UV-vis absorbance spectroscopy...

Protein Enzyme Kinetics
Mechanisms of enzyme catalysis are important to many researchers in the area of biochemistry.  The most common methods of enzyme activity measurement involve monitoring absorbance or fluorescence of a solution of enzyme and substrate as a function of time...

Protein/Ligand Interactions
Spectroscopic techniques are frequently used to quantify interactions of proteins with ligands.  Fluorescence probes, both intrinsic and extrinsic, often undergo spectral changes upon ligand binding to the protein. In addition to fluorescence, absorbance and CD can be utilized for binding studies...

Protein Secondary Structure
Protein secondary structure is an important consideration when studying protein folding, protein stability, or enzyme activity. Circular dichroism and second derivative absorbance are common methods of measurement...

Chemistry-Kinetics
Reaction kinetics are an important component of chemical research in the laboratory and in the classroom. Kinetic reactions can be triggered by a variety of methods including manual mixing, stopped flow mixing, or flash photolysis...

Mitochondria Metabolism
A highly scattering sample will increase the apparent absorbance in the vast majority of spectrophotometers on the market.  The instrument cannot differentiate between scattered and absorbed light. This artifact, however, severely limits true absorbance measurements in turbid samples...

The following applications are still under construction. Thank you for your patience!

Photochemistry

Molecular characterization (organic molecules)

Molecular characterization (metal complexes)

Nanoparticle characterization

Chemical Education: Reaction kinectics

Molecular characterization by fluorescence

A little more about Olis innovation

Olis, Inc.'s innovative bent has spawned specialized and exclusive instruments. We offer the only circular dichroism spectrometer in the world capable of operating without a lock-in amplifier. We hold the patent on a rapid-scanning monochromator which supports collection of 1,000 scans per second. In 2006, we introduced a compact, fast, and precise line of UV/Vis and NIR “Hummingbird” monochromators, around which modular single or multiple purpose spectrophotometers are built. Among these is an affordable small fluorometer which supports acquisition rates in the second, millisecond, and microsecond time regimes. In 2007, we introduced “spectacularly” sensitive NIR CD, CPL, and Polarization of Fluorescence spectrophotometers, which utilize liquid crystal variable retardance in place of piezo-elastic modulators.

And complimenting this all-new product line is our vintage line, wherein the best classic spectrophotometers of the 1960-1980s become fully competitive alternatives to much more expensive new models. Hundreds of Cary 14/17, SLM 8000, and Aminco DW-2 models have been completely electromechanically modernized and computerized, giving them decades of continuing utility.